GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs2274459 | 1 | rs13200063 | chr6:33730171 | IP6K3 | chr6:33689443-33714762:- | 0.27 | 4.61 | 4.51E-6 | Obesity (extreme) |
| BRCA | cis | rs13191362 | 1 | rs13200329 | chr6:163004418 | PACRG | chr6:163148164-163736523:+ | 0.21 | 4.14 | 3.82E-5 | Body mass index |
| BRCA | cis | rs853679 | 1 | rs13200462 | chr6:28218199 | HIST1H4J | chr6:27791903-27792257:+ | -0.19 | -3.58 | 0.000358 | Depression |
| BRCA | cis | rs853679 | 1 | rs13200462 | chr6:28218199 | ZNF389 | chr6:28129551-28137375:+ | -0.2 | -3.48 | 0.000531 | Depression |
| BRCA | cis | rs853679 | 1 | rs13200462 | chr6:28218199 | ZSCAN23 | chr6:28393287-28411279:- | 0.17 | 3.56 | 0.000387 | Depression |
| BRCA | cis | rs13191362 | 1 | rs13201023 | chr6:162981381 | PACRG | chr6:163148164-163736523:+ | 0.25 | 4.6 | 4.73E-6 | Body mass index |
| BRCA | cis | rs13215566 | 1 | rs13201083 | chr6:89918597 | GABRR1 | chr6:89887223-89927496:- | 0.17 | 3.44 | 0.000595 | Spherical equivalent (joint main effects and education interaction) |
| BRCA | cis | rs13191362 | 1 | rs13202339 | chr6:163081812 | PACRG | chr6:163148164-163736523:+ | 0.26 | 4.59 | 5.06E-6 | Body mass index |
| BRCA | cis | rs13191362 | 1 | rs13204013 | chr6:163002480 | PACRG | chr6:163148164-163736523:+ | 0.25 | 4.59 | 5.06E-6 | Body mass index |
| BRCA | cis | rs13191362 | 1 | rs13204439 | chr6:163015358 | PACRG | chr6:163148164-163736523:+ | -0.21 | -4.16 | 3.41E-5 | Body mass index |
| BRCA | cis | rs13191362 | 1 | rs13207239 | chr6:163008772 | PACRG | chr6:163148164-163736523:+ | 0.23 | 4.39 | 1.24E-5 | Body mass index |
| BRCA | cis | rs13191362 | 1 | rs13207671 | chr6:162979056 | PACRG | chr6:163148164-163736523:+ | 0.25 | 4.56 | 5.64E-6 | Body mass index |
| BRCA | cis | rs11976180 | 1 | rs1320893 | chr7:143752112 | ARHGEF35 | chr7:143883677-143892736:- | -0.38 | -9.62 | 4.55E-21 | Obesity-related traits |
| BRCA | cis | rs11976180 | 1 | rs1320893 | chr7:143752112 | OR2A7 | chr7:143955790-143974852:- | 0.21 | 5.19 | 2.54E-7 | Obesity-related traits |
| BRCA | cis | rs11976180 | 1 | rs1320894 | chr7:143751802 | ARHGEF35 | chr7:143883677-143892736:- | -0.41 | -10.21 | 2.09E-23 | Obesity-related traits |